acerola vitamine C en A vrucht

 

Acerola Bio - de vitamine C bom

Informatie over gezonde voeding


De voordelen van deze Zuid-Amerikaanse bes

Acerola bes


acerola.jpg (83817 bytes)

U bent op zoek naar de vrucht met de meeste vitamine C ?

Uit Brazili komt deze superbes die het meeste vitamine C bevat van alle fruitsoorten. Naast vitamine C bevat het nog veel betacaroteen dat ook in bijvoorbeeld wortelen zit, het lichaam kan hiervan vitamine A maken.

De bes is helaas niet vers te koop in Nederland maar wel wordt hij steeds meer in supplementen gebruikt als vervanger van chemische vitamine C.
In Amerika kun je terecht voor Acerola in capsule/tablet en poedervorm.

Mocht je nu vitamine C slikken dan grote kans dat dit een synthetische versie is (ascorbaat) en niet van een natuurlijke bron. Wil je echt een natuurlijke vitamine C slikken dan is Acerola een goede aanvulling op vers fruit.

De meeste vitamine C tabletten bevatten maar een klein deel (chemische) vitamine C, je zit dan ook al gauw op kiloprijzen van 100-300 euro. Acerola poeder is al te koop voor rond de 50 euro per 500 gram (bel voor info 0346-330038) en dan dus stuk voordeliger en natuurlijker.

Ik heb hieronder een voedingswaarde lijst gezet van de Amerikaanse overheid zodat je kan zien dat deze bes extreem veel vitamine C bevat.
Als je uitgaat van de norm van het Voedingscentrum van rond de 60mg
dan zit je bij 4 gram bessen (is ongeveer 0.4 gram poeder) al op de dosis
die je volgens hun nodig hebt. Een sinasappel bevat ook ongeveer
60mg vitamine C.

Ron


 

Acerola raw berry
Scientific Name: Malpighia punicifolia
NDB No: 09001 (Nutrient values and weights are for edible portion)

Nutrient Units Value per
100 grams
Proximates
Water

g

91.41

Energy

kcal

32

Energy

kj

134

Protein

g

0.40

Total lipid (fat)

g

0.30

Ash

g

0.20

Carbohydrate, by difference

g

7.69

Fiber, total dietary

g

1.1

Minerals
Calcium, Ca

mg

12

Iron, Fe

mg

0.20

Magnesium, Mg

mg

18

Phosphorus, P

mg

11

Potassium, K

mg

146

Sodium, Na

mg

7

Zinc, Zn

mg

0.10

Copper, Cu

mg

0.086

Selenium, Se

mcg

0.6

Vitamins
Vitamin C, total ascorbic acid

mg

1677.6

Thiamin

mg

0.020

Riboflavin

mg

0.060

Niacin

mg

0.400

Pantothenic acid

mg

0.309

Vitamin B-6

mg

0.009

Folate, total

mcg

14

Folate, food

mcg

14

Folate, DFE

mcg_DFE

14

Vitamin B-12

mcg

0.00

Vitamin A, IU

IU

767

Vitamin A, RAE

mcg_RAE

38

Lipids
Fatty acids, total saturated

g

0.068

14:0

g

0.002

16:0

g

0.048

18:0

g

0.016

Fatty acids, total monounsaturated

g

0.082

16:1 undifferentiated

g

0.001

18:1 undifferentiated

g

0.081

Fatty acids, total polyunsaturated

g

0.090

18:2 undifferentiated

g

0.046

18:3 undifferentiated

g

0.044

Cholesterol

mg

0

Other
Alcohol, ethyl

g

0.0

(C) USDA National Nutrient Database for Standard Reference



Vitamine C informatie

Ascorbinezuur of vitamine C is een in water oplosbare stof die van nature in veel soorten fruit voorkomt. In 1928 is deze stof door Albert Szent-Gyrgyi gesoleerd uit de cortex van de bijnier. Als voedingssupplement wordt het in poedervorm en in tabletvorm verkocht. Het wordt vaak als conserveermiddel toegevoegd aan levensmiddelen. Het E-nummer van ascorbinezuur is E300.

Van ascorbinezuur afgeleide zouten heten ascorbaten.

Iedere mens heeft voor de stofwisseling behoefte aan een kleine hoeveelheid ascorbinezuur per dag; een dagelijkse dosis van 60 milligram verspreid over de dag wordt aanbevolen. Volgens Nobelprijswinnaar Linus Pauling zou de dagelijkse inname 2,3 tot 9,5 gram moeten bedragen. De verspreiding over de dag is belangrijk, omdat vitamine C vrij snel wordt afgebroken. De halfwaarde tijd van vitamine C, direct in de ader ingespoten, bedraagt 30 minuten.

Zelfs van veel grotere hoeveelheden zijn geen negatieve gezondheidseffecten bekend; vitamine-C tabletten in de handel bevatten tot wel 1000mg ascorbinezuur, vaak als combinatie van het zuur met zouten om een zuuraanval op de maag te voorkomen. De positieve effecten van zulke grote hoeveelheden zijn echter niet objectief vastgesteld. Linus Pauling had een theorie dat grote hoeveelheden vitamine C per dag kanker zouden kunnen voorkomen; hijzelf gebruikte circa 11.000 milligram per dag. Mensen die grote hoeveelheden vitamine C gebruiken moeten dit bij medisch onderzoek melden, omdat het bloedbeeld er door veranderd wordt en een arts anders een verkeerde diagnose kan stellen. Dr. Frederick R. Klenner heeft vitamine C als geneesmiddel toegepast door de dosis sterk te verhogen. Tientallen grammen vitamine C per dag toedienen doormiddel van injecties was geen uitzondering. Vooral bij virale infecties zijn hiermee zeer positieve resultaten bereikt.

Veel planten en dieren zijn in staat om hun eigen vitamine C te maken met behulp van enzymen vanuit glucose. Mensen kunnen als gevolg van een gendefect het enzym L-gulonolactone oxidase niet aanmaken waardoor de synthese van vitamine C niet kan plaatsvinden. Mensen zijn afhankelijk van inname van voedsel dat vitamine C bevat.

Bekend is dat vooral in vroegere tijden zeelieden stierven aan scheurbuik ten gevolge van gebrek aan vitamine C.

[Bron: Wikipedia]


Op zoek naar gedroogde acerola poeder?

Kijk dan op www.supervoeding.com


Vitamine C of ascorbinezuur is veruit de meest bekende vitamine. Al in de zestiende eeuw wisten zeelieden dat citrusvruchten en verse groente scheurbuik konden voorkomen. Pas veel later werd bekend dat deze ziekte verband hield met een ernstig tekort aan vitamine C. Deze vitamine is oplosbaar in water en is betrokken bij een groot aantal processen in het lichaam. Vitamine C is onder meer nodig voor de vorming van bindweefsel en deze zorgt voor een goede wondgenezing. Verder zorgt vitamine C ervoor dat ijzer uit de voeding beter wordt opgenomen en speelt het een belangrijke rol bij het instandhouden van de weerstand. Vitamine C staat sterk in de belangstelling vanwege zijn rol als antioxidant. Antioxidanten zijn stoffen waarvan men vermoedt dat zij het lichaam kunnen beschermen tegen het ontstaan van kanker en hart- en vaatziekten.

[Bron: Voedingscentrum]

 

Overige nieuwtjes

  • Hoge dosis vitamine C veroorzaakt g?n nierstenen
  • Gunstig effect van vitamine C bij artrose
  • Protectieve invloed van vitamine C tegen cognitieve achteruitgang
    en beroerte
  • Vitamine C helpt wel degelijk tegen verkoudheid
  • Vitamine C beschermt hart bij sepsis
  • Vitamine C ter beperking van hersenbeschadigingen na beroertes
  • Positieve resultaten met hoge doses vitamine C bij niet-insuline-afhankelijke diabetes

    Meer info hier

 

Wetenschappelijke onderzoeken naar Vitamine C

 

Ascorbic acid protects lipids in human plasma and low-density lipoprotein against oxidative damage

B Frei
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115.

We exposed human blood plasma and low-density lipoprotein (LDL) to many different oxidative challenges and followed the temporal consumption of endogenous antioxidants in relation to the initiation of oxidative damage. Under all types of oxidizing conditions, ascorbic acid completely protects lipids in plasma and LDL against detectable peroxidative damage as assessed by a specific and highly sensitive assay for lipid peroxidation. Ascorbic acid proved to be superior to the other water-soluble plasma antioxidants bilirubin, uric acid, and protein thiols as well as to the lipoprotein-associated antioxidants alpha-tocopherol, ubiquinol-10, lycopene, and beta-carotene. Although these antioxidants can lower the rate of detectable lipid peroxidation, they are not able to prevent its initiation. Only ascorbic acid is reactive enough to effectively intercept oxidants in the aqueous phase before they can attack and cause detectable oxidative damage to lipids.


Orange Juice Ingestion and Supplemental Vitamin C Are Equally Effective at Reducing Plasma Lipid Peroxidation in Healthy Adult Women

Carol S. Johnston, PhD, FACN, Candice L. Dancho, MS and Gail M. Strong, MS
Department of Nutrition, Arizona State University East, Mesa, Arizona

Carol Johnston, Ph.D., Department of Nutrition, Arizona State University East, 7001 E. Williams Field Rd, Mesa, AZ 85212. E-mail: carol.johnston@asu.edu

Objective: To directly examine the contribution of vitamin C to the antioxidant potential of fruits and vegetables, the antioxidant effect of orange juice consumption (8 and 16 fl. oz.) was compared to the antioxidant effect of supplemental vitamin C (dosage equivalent to that supplied by 8 fl. oz. of orange juice).

Methods: Subjects (n = 11; 28.6 2.1 years) received each treatment in a 3 x 3 randomized crossover design, and each two-week treatment was preceded by a two-week washout. During the entire trial, subjects restricted fruit and vegetable consumption to 3 servings per day except the vitamin C-rich foods (items containing >20 mg/serving), which were restricted to 3 servings per week. A fasting blood sample was collected at the end of each washout and each treatment period.

Results: Following washouts, plasma vitamin C and lipid peroxidation (plasma TBARS) were similar by treatment group and averaged 25.4 3.6 mol/L and 3.82 0.10 nmol/mL respectively. Plasma vitamin C concentrations were similar following each treatment period, 37.9 8.1, 45.8 9.4, and 38.3 12.4 mol/L for the 8 and 16 fl. oz. orange juice treatments and the supplement treatment, respectively. All intervention treatments reduced plasma TBARS as compared to pretreatment values: -47% (p = 0.013), -40% (p = 0.083), and -46% (p = 0.015) for the 8 and 16 fl. oz. orange juice treatments and supplement treatment respectively.

Conclusions:These data indicate that the regular consumption of 8 fl. oz. orange juice or supplemental vitamin C (70 mg/day) effectively reduced a marker of lipid peroxidation in plasma.

Full report here


Fruits and vegetables in the prevention of cancer and cardiovascular disease

van't Veer P, Jansen MC, Klerk M, Kok FJ.

Division of Human Nutrition and Epidemiology, Wageningen University, The Netherlands. pieter.vantveer@staff.nutepi.wau.nl

OBJECTIVE: We quantified the public health benefit of fruits and vegetables on the prevention of cancer and cardiovascular disease (CVD), using currently available human data. DESIGN: We reviewed over 250 observational studies on cancer and CVD. Relative risks (RRs) for high versus low intake of fruits and vegetables were obtained. The preventable proportion of chronic diseases, i.e. the per cent of cases attributable to low consumption of fruits and vegetables, was estimated using three scenarios: best guess, optimistic (using stronger RRs) and conservative (using weaker RRs and eliminating the contribution of smoking and/or drinking). The preventable proportion was calculated for increasing average intake from the current 250 g day(-1) to the recommended 400 g day(-1) among the general Dutch population.

RESULTS: It is estimated that in the Netherlands cancer incidence could be reduced by 19% (12,000 cases annually, best guess), ranging from 6% (conservative) to 28% (optimistic). Cardiovascular deaths could be reduced by 16% (8000 deaths annually, best guess), ranging from 6% to 22%. Evidence is most abundant for gastrointestinal cancers, followed by hormone-related cancers, but limited for other sites and CVD.

CONCLUSIONS: Increasing consumption of fruits and vegetables carries a large public health potential. Population trials and biological mechanisms should eventually provide scientific proof of their efficacy. The available evidence is sufficient to justify public health education and promotion aimed at a substantial increase in the consumption of fruits and vegetables.


Bases to determine the dose of vitamin C in pregnancy

Casanueva E, Angulo ME, Goidberg S, Pfeffer F, Meza-Camacho C, Vadillo-Ortega F, Rothenberg SJ.

Instituto Nacional de Perinatologia, Mexico. casanuev@servidor.unam.mx

OBJECTIVE: Determine the dose of Vitamin C able to maintain a leukocyte Vitamin C concentration of > or =18 microg/10(8) cells, in pregnant women with 28 to 32 weeks of gestation, in order to compile a database to estimate the daily recommended intake (DRI) during pregnancy. METHODOLOGY: Stage 1: acute supplementation study. A group of 10 healthy women in late first and early second trimester pregnancy were supplemented with 0 to 200 mg vitamin C/day during one week each. Stage 2: a randomized double blind study (placebo vs. vitamin C [100 mg/d]) was carried out with 52 women studied from week 20 to week 32 of pregnancy. Their plasma and leukocyte vitamin C concentrations were measured every 4 weeks to evaluate the previously established supplementation dose.

RESULTS: Stage 1: with the 100 mg/day dose, leukocyte vitamin C saturation was reached without increasing urinary excretion.

Stage 2: leukocyte concentration of vitamin C decreased throughout pregnancy in women receiving placebo, while supplemented women maintained their concentrations > or =18 microg/10(8) cells.

CONCLUSION: A 100 mg/day dose of vitamin C during the second half of pregnancy keeps leukocyte storage and could be useful to establish the DRI of Vitamin C during pregnancy.


Effects of vitamin C on intracoronary L-arginine dependent coronary vasodilatation in patients with stable angina.

Tousoulis D, Xenakis C, Tentolouris C, Davies G, Antoniades C, Crake T, Stefanadis C.

Athens University Medical School, Athens, Greece. drtousoulis@hotmail.com

OBJECTIVE: To assess the effects of intravenous vitamin C administration on the vasomotor responses to intracoronary L-arginine infusion in epicardial coronary arteries. METHODS: 28 patients with coronary artery disease and stable angina were enrolled in the study. Eight patients received intracoronary infusions of 150 micromol/min L-arginine before and after intravenous infusion of vitamin C, 10 patients received intracoronary infusions of 150 micromol/min L-arginine before and after intravenous infusion of normal saline, and 10 patients received intracoronary normal saline before and after intravenous infusion of vitamin C. The diameter of proximal and distal coronary artery segments was measured by quantitative angiography.

RESULTS: Infusion of L-arginine caused significant dilatation of both proximal (4.87 (0.96)%, p < 0.01 v normal saline) and distal (6.33 (1.38)%, p < 0.01 v normal saline) coronary segments. Co-infusion of vitamin C and L-arginine dilated proximal coronary segments by 8.68 (1.40)% (p < 0.01 v normal saline, p < 0.01 v L-arginine) and distal segments by 13.07 (2.15)% (p < 0.01 v normal saline, p < 0.01 v L-arginine). Intravenous infusion of vitamin C caused a borderline increase in proximal and distal coronary segment diameters (1.93 (0.76)% and 2.09 (1.28)%, respectively, not significant).

CONCLUSIONS: L-arginine dependent coronary segment vasodilatation was augmented by the antioxidant vitamin C in patients with coronary artery disease.

Thus, vitamin C may have beneficial effects on nitric oxide
bioavailability induced by L-arginine.


Effect of Five-Year Supplementation of Vitamin C on Serum Vitamin C Concentration and Consumption of Vegetables and Fruits in Middle-Aged Japanese: A Randomized Controlled Trial

Mi Kyung Kim, PhD, Shizuka Sasazuki, MD, Satoshi Sasaki, MD, Shunji Okubo, MD, Masato Hayashi, MD and Shoichiro Tsugane, MD
Epidemiology & Biostatistics Division, National Cancer Center Research Institute East, Chiba (M.K.K., S.S., S.S., S.T.), JAPAN
Hiraka General Hospital, Yokote (S.O., M.H.), JAPAN

Address reprint requests to: Shoichiro Tsugane, M.D., Epidemiology and Biostatistics Division, National Cancer Center Research Institute, 6-5-1 Kashiwanoha, Kashiwa City, Chiba 277-8577, JAPAN. E-mail: stsugane@east.ncc.go.jp

Objective: This study was aimed at evaluating the effect of long-term vitamin C supplementation on serum and dietary vitamin C and identifying the factors associated with change in serum concentration.

Methods: A total of 439 subjects with atrophic gastritis initially participated in a randomized clinical trial using vitamin C and -carotene to prevent gastric cancer. We originally randomized the participants into four treatment groups using a 2x2 factorial design, whereby 0 or 15 mg/day -carotene and 50 or 500 mg/day vitamin C were administered in a double-blind manner. The -carotene component was terminated early after a mean treatment duration of four months. Before and upon early termination of -carotene supplementation, 134 subjects dropped out this trial, while 120 and 124 subjects took the vitamin C supplement at either 50 mg or 500 mg daily for five years.

Results: Changes in serum vitamin C were significantly higher in the high-dose group (38.5% increase, 95% CI = 27.0–49.9) than in the low-dose group (13.0% increase, 5.1–20.9) or in the dropout group (3.3% increase, -2.1–8.6) after five-year supplementation. The serum vitamin C at baseline was negatively associated with changes in serum vitamin C (p < 0.0001), while high-dose (p < 0.0001) and low-dose (p < 0.05) supplementation and female gender (p < 0.001) were positively associated. Dietary intake of vitamin C in the supplementation group was almost identical before and after five-year supplementation of vitamin C (2.31 mg/day decrease, 95% CI = -15.3–10.7), while a 17.7 mg/day decrease (95% CI = -44.2–8.86) was observed in the drop-out group.

Conclusion: Five-year vitamin C supplementation induces a remarkable increase in serum vitamin C concentration, and our intervention program appears to have no effect on dietary vitamin C intake.


Plasma-Saturating Intakes of Vitamin C Confer Maximal Antioxidant Protection to Plasma

Carol S. Johnston, PhD, FACN and Sarah K. Cox, MS
Department of Nutrition, Arizona State University East, Mesa, Arizona

Address reprint requests to: Carol Johnston, PhD, Department of Nutrition, Arizona State University East, 7001 E. Williams Field Rd, Mesa, AZ 85212. Email: carol.johnston@asu.edu.

Objective: Supplemental vitamin C has been shown to reduce oxidative damage in vivo, yet the dose-response relationship between vitamin C intake and antioxidant protection is not known. This report examined blood indicators of oxidative stress in subjects consuming graded doses of vitamin C, from 75 to 2000 mg/day.

Methods: Ten healthy, non-smoking men and women (26.1 2.1 years) were recruited from a campus population. During the ten-week study, subjects limited fruit and vegetable consumption (3 servings/day) and consumed a multivitamin and mineral pill daily. Beginning at week 3, subjects ingested either a vitamin C (n = 8) or placebo (n = 2) capsule, which were identical in appearance and taste. The content of the vitamin C capsule increased every two weeks (from 250 mg at weeks 3–4 to 500 mg, 1000 mg, and 2000 mg at weeks 5–6, 7–8, 9–10, respectively). Fasting blood samples were collected at two-week intervals and analyzed for vitamin C, total lipid hydroperoxides and Heinz bodies in packed erythrocytes incubated 24 hours at 37.

Results: Plasma vitamin C rose 55% in vitamin C-supplemented subjects by the end of the ten-week treatment (p < 0.05), and measures of oxidative stress decreased 60% to 90% (8.1 0.6 to 3.5 0.4 nmol/mL and 69.1 7.8% to 6.7 6.0% for total lipid hydroperoxides and Heinz bodies, respectively). Significant decreases in markers of oxidative stress were noted at the 500 mg, 1000 mg and 2000 mg dosages versus placebo. Antioxidant protection was similar at the 1000 mg and 2000 mg dosage.

Conclusions: These data indicate that the antioxidant protection afforded by short-term vitamin C supplementation is maximal at the 500–1000 mg dosage range.


Intakes of Vitamin C, Vegetables and Fruits: Which Schoolchildren Are at Risk?

Jeffrey S Hampl, PhD, RD, Christopher A. Taylor and Carol S. Johnston, PhD, RD, FACN Graduate Program in Human Nutrition, Arizona State University, Tempe, Arizona

Address reprint requests to: Jeffrey S Hampl, PhD, RD, Graduate Program in Human Nutrition, Arizona State University, Box 872502, Tempe, AZ 85287-2502

Objective: The purpose of this study was to determine vitamin C intakes among American schoolchildren. We investigated the leading sources of vitamin C in children’s diets, the leading vegetables and fruits consumed by children and differences in dietary intake associated with vitamin C consumption.

Methods: Data from 1,350 7- to 12-year-old and 908 13- to 18-year-old schoolchildren were obtained from the 1994–1996 Continuing Survey of Food Intakes by Individuals (CSFII). The children were stratified by age and gender and then split into three vitamin C consumption groups based upon two 24-hour recalls: low (0 to 30.0 mg), marginal (30.1 to 59.9 mg), and desirable (>60.0 mg). Data were analyzed by tabulation and by ANOVA followed by post hoc Scheffe’s test. Outcome measures included food groups and energy-adjusted intakes of micro- and macronutrients.

Results: Among the 7- to 12-year-olds, 12% of boys and 13% of girls had mean vitamin C intakes that were less than 30 mg/day, and, among 13- to 18-year-olds, 14% of boys and 20% of girls had low vitamin C intakes. In addition to consuming significantly more vitamin C, children with desirable vitamin C intakes also consumed significantly more (p <0.001) energy-adjusted folate and vitamin B6; children with low vitamin C intakes tended to have significantly greater (p <0.001) energy-adjusted intakes of fat and saturated fat. Children with desirable vitamin C intakes consumed significantly more (p <0.006) high-vitamin C fruit juice, low-vitamin C vegetables and whole milk. Children with low vitamin C intakes on average consumed two daily servings of vegetables and fruits, of which less than of a serving was citrus, while children with desirable vitamin C intakes consumed an average of one daily serving of citrus.

Conclusions: A considerable number of children drastically under-consumed vitamin C and total vegetables and fruits. Overall, children with desirable vitamin C intakes had healthier diets, including more milk and vegetables, than did their peers with low vitamin C intakes. Health care professionals should continue to promote at least five daily servings of vegetables and fruits and should advise parents that at least one of these should be rich in vitamin C.


The Influence of Smoking on Vitamin C Status During the Third Trimester of Pregnancy and on Vitamin C Levels in Maternal Milk

Rosa M. Ortega, PhD, FACN, Ana M. Lpez-Sobaler, PhD, M. Elena Quintas, PhD, Rosa M. Martnez, PhD and Pedro Andrs, PhD
Departamento de Nutricin (R.M.O., A.M.L-S., E.Q.), Facultad de Farmacia, Universidad Complutense, Madrid SPAIN
Servicio de Anlisis Clnicos, Servicio de Obstetricia y Ginecologa (R.M.M.), Hospital INSALUD, Cuenca SPAIN
Laboratorio de Tcnicas Instrumentales (P.A.), Facultad de Farmacia. Universidad Complutense, Madrid SPAIN

Address reprint requests to: Rosa M. Ortega, PhD, FACN, Departamento de Nutricin, Facultad de Farmacia, Universidad Complutense, 28040-Madrid SPAIN

Objective: The aim of the present investigation was to determine the differences in vitamin C status of 57 Spanish women smokers (S) and nonsmokers (N) in their third trimester of pregnancy, and the concentrations of vitamin C in their milk.

Methods: Vitamin C intake during the third trimester was determined by recording the consumption of foods over a 5-day period (including a Sunday) and by registering vitamin C provided by dietary supplements. Vitamin C levels in maternal serum during this stage of pregnancy and in transition (days 13 to 14 of lactation) and mature milk (day 40 of lactation) were determined colorimetrically. Subjects also answered a questionnaire on their smoking habits during pregnancy.

Results: S subjects (n=16) showed a lower intake of fruits, vegetables and vitamin C than did N subjects (n=41), though these differences were not significant (17.1% of N subjects and 31.2% of S subjects took less than 80 mg of vitamin C per day). Neither were any differences found between the two groups in serum vitamin C levels. However, N subjects showed significantly greater vitamin C levels in both transition and mature milk (431.6296.5 mol/L and 496.1325.6 mol/L, respectively for N subjects, and 233.7202.9 mol/L and 241.3293.1 mol/L for S subjects). Further investigations are necessary to determine the clinical consequences of these observations, though it is already known that maternal smoking favors peroxidation events in newborn infants.

Conclusions: If the concentration of antioxidants (vitamin C) in smokers’ breast milk is also lower, this might aggravate the peroxidation problems of their newborn.


Micronutrient Deficiencies as Predisposing Factors for Hypertension in Lacto-Vegetarian Indian Adults

Shashi A. Chiplonkar, PhD, Vaishali V. Agte, PhD, Kirtan V. Tarwadi, MSc, Kishor M. Paknikar, PhD and Uma P. Diwate, MD
Agharkar Research Institute (S.A.C., V.V.A., K.V.T., K.M.P.), H.C., Pune, INDIA
Jehangir Medical Research Institute (U.P.D.), Pune, INDIA

Address reprint requests to: Dr. Shashi A. Chiplonkar, Biometry & Nutrition Group, Agharkar Research Institute, G. G. Agarkar Road, Pune, 411 004, INDIA. E-mail: shashi49@indiainfo.com

Objective: With the increasing knowledge about the antioxidant potential of many micronutrients such as zinc and vitamin C, their roles in oxidative stress related health disorders have been postulated. This study therefore investigated low micronutrient status as a predisposing factor for hypertension in a traditionally lacto-vegetarian population like Indians.

Methods: Micronutrient profile was assessed in 109 hypertensives with age-gender-socio-economic status matched 115 healthy normotensives (30–58 years of age). Food intakes were estimated through a semi-quantitative food frequency questionnaire. Nutrient intakes were then evaluated by previous estimates of cooked foods from our laboratory. Systolic and diastolic blood pressure (SBP, DBP), age, weight, height, waist and hip circumference, occupation, physical activity, smoking habits were recorded. Fasting blood samples were analyzed for hemoglobin, serum level of glucose, triglycerides, total cholesterol, HDL, ceruloplasmin, plasma level of ascorbic acid, folic acid, retinol, erythrocyte glutathione reductase activity coefficient (EGRAC) and erythrocyte membrane zinc.

Results: There were no significant differences between protein, fat intakes of normal and hypertensive individuals, though intakes of men were higher than those of women (p < 0.05). Intakes of omega-6 fatty acids were higher (p = 0.08) and omega-3 fatty acids were lower in hypertensive men than normotensive men (p = 0.04). Gender differences were also significant for micronutrient intakes except vitamin C and -carotene. Intakes of potassium, copper, folic acid and vitamin C were significantly lower in hypertensive individuals than in normotenisves. No significant association was found between occupation or activity level and hypertension (p > 0.2) in these subjects. Conditional logistic regression analysis indicated that intakes of vitamin C, folic acid and zinc were associated with 18% (OR = 1.18, 95% CI:1.08, 1.26), 51% (OR = 1.51, 95% CI 0.94, 2.1) higher odds for hypertension, and 3% lower odds for hypertension (OR = 0.97, 95% CI 0.92, 1.01), respectively. Mean plasma vitamin C and folic acid were significantly higher (p < 0.01), and serum ceruloplasmin and erythrocyte membrane zinc were marginally higher (p = 0.07) in normal than hypertensive subjects. In multivariate linear regression analyses, plasma vitamin C, serum ceruloplasmin and erythrocyte membrane zinc were negatively associated with SBP (p = 0.00001) and plasma vitamin C was negatively associated with DBP (p = 0.0001).

Conclusion: Low dietary intakes of vitamin C, folic acid and zinc emerged as the possible risk factors for hypertension. Further, lower levels of plasma vitamin C, erythrocyte membrane zinc and ceruloplasmin were found to be the putative intermediary biomarkers in pathogenesis of hypertension.


Low intake of fruits, berries and vegetables is associated with excess mortality in men: the Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study.

Rissanen TH, Voutilainen S, Virtanen JK, Venho B, Vanharanta M, Mursu J, Salonen JT.

Research Institute of Public Health, University of Kuopio, Finland.

Diets rich in fruits and vegetables have been of interest because of their potential health benefits against chronic diseases such as cardiovascular disease (CVD) and cancer. The aim of this work was to assess the association of the dietary intake of a food group that includes fruits, berries and vegetables with all-cause, CVD-related and non-CVD-related mortality. The subjects were Finnish men aged 42-60 y examined in 1984-1989 in the prospective Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study. Dietary intakes were assessed by 4-d food intake record during the baseline phase of the KIHD Study. The risk of all-cause and non-CVD-related deaths was studied in 2641 men and the risk of CVD-related death in 1950 men who had no history of CVD at baseline. During a mean follow-up time of 12.8 y, cardiovascular as well as noncardiovascular and all-cause mortality were lower among men with the highest consumption of fruits, berries and vegetables. After adjustment for the major CVD risk factors, the relative risk for men in the highest fifth of fruit, berry and vegetable intake for all-cause death, CVD-related and non-CVD-related death was 0.66 [95% confidence interval (CI) 0.50-0.88], 0.59 (0.33-1.06), and 0.68 (0.46-1.00), respectively, compared with men in the lowest fifth. These data show that a high fruit, berry and vegetable intake is associated with reduced risk of mortality in middle-aged Finnish men. Consequently, the findings of this work indicate that diets that are rich in plant-derived foods can promote longevity.

Full article here


Vitamin C enhances chemosensitization of esophageal cancer cells in vitro.

Abdel-Latif MM, Raouf AA, Sabra K, Kelleher D, Reynolds JV.

Department of Surgery, Trinity Centre for Health Sciences, St James's Hospital, Dublin, Ireland. abdellmm@tcd.ie

Chemotherapy is increasingly utilised in multimodal protocols to try and improve outcomes. Cisplatin and 5-fluorouracil (5-Fu) are the mainstay of chemotherapeutic regimens, and an understanding of sensitivity and resistance of esophageal cancer to these agents is of considerable clinical importance. Antioxidants may modulate the response to chemotherapy, and in this study we examined the effect of vitamin C on 5-Fu and cisplatin cytotoxicity and related pathways in the esophageal cancer cell lines OE33 and SKGT-4. The antiproliferative effect of antitumor agents was measured by the MTT assay, and the transcription factors NF-kappaB and AP-1 pathways were assessed by electrophoretic mobility gel shift assay. 5-Fu and cisplatin demonstrated marked morphological changes and decreased cell proliferation. A combination of vitamin C with 5-Fu or cisplatin exerted a significantly enhanced cytotoxic effect compared to both drugs individually. Treatment of esophageal cancer cells with 5-Fu and cisplatin induced NF-kappaB and AP-1 activation. Pretreatment with vitamin C inhibited 5-Fu or cisplatin induced NF-kappaB nuclear translocation and DNA binding activity, but vitamin C had no effect on IkappaB-alpha protein levels. Vitamin C also inhibited 5-Fu- and cisplatin-induced AP-1 activation.

Our data demonstrate that vitamin C enhances the antitumor activity of 5-Fu and cisplatin, in part by inhibiting translocation of NF-kappaB and AP-1, and sensitizes cancer cells to drug-induced cell death. The data suggest that vitamin C supplementation may improve the efficacy of chemotherapy for esophageal cancer.


Supplementation with flax oil and vitamin C improves the outcome of Attention Deficit Hyperactivity Disorder (ADHD).

Joshi K, Lad S, Kale M, Patwardhan B, Mahadik SP, Patni B, Chaudhary A, Bhave S, Pandit A.

Interdisciplinary School of Health Sciences (ISHS), University of Pune, Ganeshkhind, Pune-411007, Maharashtra, India.

Considerable clinical and experimental evidence now supports the idea that deficiencies or imbalances in certain highly unsaturated fatty acids may contribute to a range of common developmental disorders including Attention Deficit Hyperactivity Disorder (ADHD). Few intervention studies with LCPUFA supplementation have reported inconsistent and marginal results. This pilot study evaluates the effect of alpha linolenic acid (ALA)-rich nutritional supplementation in the form of flax oil and antioxidant emulsion on blood fatty acids composition and behavior in children with ADHD. Post-supplementation levels of RBC membrane fatty acids were significantly higher than pretreatment levels as well as the levels in control.

There was significant improvement in the symptoms of ADHD reflected by reduction in total hyperactivity scores of ADHD children derived from ADHD rating scale.


Vitamin C and E supplements may prevent hardening of the arteries in heart transplant patients - Laurie LaRusso, MS, ELS

Arteriosclerosis (hardening of the arteries) occurs in 70% of heart transplant patients within three years after transplantation. A process called oxidative stress is believed to contribute to this accelerated development of arteriosclerosis among heart transplant patients. Researchers know, however, that certain compounds in the body called antioxidants can protect cells from oxidative stress. Researchers from Brigham and Women?s Hospital in Boston and the Linus Pauling Institute at Oregon State University tested the hypothesis that antioxidants could reduce oxidative stress, and subsequently inhibit the development of arteriosclerosis in heart transplant patients. Their results, recently published in The Lancet, suggest that taking the antioxidant vitamins C and E after heart transplant surgery may help prevent transplant-induced arteriosclerosis.

More here


Nuttige links

Chlorella Alg
Deze alg uit Japan en Korea helpt u snel uw gezondheid drastische te verbeteren. De alg zorgt voor een flinke groei van uw darmflora waardoor u meer energie krijgt en de voeding beter verteerd wordt. Verder bevat de alg een zeer hoge dosis chlorophyl (bladgroen) die het lichaam helpt bij het afvoeren van metalen zoals kwik, cadnium, lood etc die veel schade aan de hersenen kunnen veroorzaken. Daarnaast bevat de alg een hoge kwaliteit plantaardig eiwit, aminozuren, mineralen en hoge dosis ijzer en betacaroteen (provitamine A)

Wat de dokter u niet vertelt - fonteine.com
Een kritische kijk op onze gezondheidszorg en haar kortzichtigheid. Kritische artikelen over zuivel, brood, verhit eten maar ook veel nuttige tips voor mensen die langer en gezonder willen leven. Uitleg over: wat is kefir ? wat is olieslurpen ? hoe voorkom ik onstekingen in de darmen ? welke rol speelt voeding bij autisme en schizofrenie ? Is er meel zonder gluten ? Is zuivel gezond ? Welk gevaar schuilt er in verzuring van het lichaam ? Hoe gezond is kokosolie ?

Succes met je gezondheid !

Ron Fonteine

Verder wil ik Luc bedanken voor zijn hulp met deze site.

Voeding en gezondheid - nieuws

Wil je leer weten over voeding en gezondheid kijk dan eens op: